Cireson Self-Service Portal with the Microsoft HTML5 portal

Can the Cireson Self-Service Portal be installed on the same server as the Microsoft 2016 HTML5 portal? Maybe on a different port or separated out with host headers? Meaning, are there any technical conflicts that might cause them to step on each other's toes?

If not, can I install the Cireson portal on a different server? 

Are there any issues to consider by having both portals in operation at the same time? Whether that be on the same server or separate servers?
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